Pancreatic diseases, particularly pancreatic cancer, are often known for causing digestive issues, abdominal pain, and weight loss. However, many people are unaware that they can also cause visible changes to the skin. These cutaneous manifestations may appear before other symptoms, acting as early warning signs of underlying pancreatic problems. Recognising these signs can help in seeking timely medical attention, improving the chances of early diagnosis and effective treatment. From jaundice to unusual rashes and nodules, understanding the connection between pancreatic disorders and skin symptoms is crucial for both patients and healthcare professionals.



Understanding pancreatic cancer and its symptoms on skin
Pancreatic cancer occurs when abnormal cells in the pancreas grow uncontrollably, forming tumours. The pancreas, located behind the stomach, plays a vital role in digestion and blood sugar regulation. Early detection is challenging because symptoms often appear late, which is why recognising skin changes can be life-saving.


Pancreatic symptoms on skin

1. Jaundice and itchy skin

Jaundice manifests as a yellowing of the skin and the whites of the eyes, often accompanied by dark urine and pale stools. This occurs when a pancreatic tumour obstructs the bile duct, leading to a buildup of bilirubin in the bloodstream. The itching (pruritus) that often accompanies jaundice is due to bile salts accumulating in the skin, causing irritation. A study published in Cancer Research UK notes that jaundice is a common symptom of pancreatic cancer, particularly when the tumour is located in the head of the pancreas, as it can compress the bile duct .


2. Pancreatic panniculitis

Pancreatic panniculitis is a rare condition characterised by painful, reddish nodules under the skin, often on the legs. These lesions are linked to elevated pancreatic enzymes and can indicate pancreatic cancer or severe pancreatitis. According to a review in DermNet NZ, pancreatic panniculitis occurs in approximately 2–3% of patients with pancreatic disease, with a higher incidence among alcoholic men .


3. Necrolytic Migratory Erythema (NME)

NME presents as red, blistering patches with irregular borders, often affecting the limbs, perineum, and groin. It is associated with glucagon-secreting pancreatic tumours called glucagonomas. NME is a distinctive skin rash that may be exacerbated by pressure or trauma to the affected areas .


4. Acanthosis nigricans

Acanthosis nigricans presents as dark, velvety patches of skin, typically in body folds such as the armpits, neck, and groin. While it is more commonly associated with insulin resistance and obesity, it can also be a paraneoplastic sign in pancreatic cancer, indicating underlying malignancy. According to ACIBADEM Health, acanthosis nigricans may appear as a paraneoplastic sign of pancreatic cancer, often indicating malignancy .


5. Cutaneous metastases

Although rare, pancreatic cancer can metastasise to the skin, presenting as nodules or plaques. These cutaneous metastases are often indicative of advanced disease and may be associated with poor prognostic outcomes. A study published in BMJ Case Reports notes that cutaneous metastasis from pancreatic cancer is rare; the most predominant manifestation is metastasis at the umbilicus .


6. Livedo reticularis

Livedo reticularis manifests as a mottled, purplish skin discolouration, often resembling a lace-like pattern. It can be seen in various systemic conditions, including pancreatic diseases, and may indicate underlying vascular or inflammatory processes. According to a review in Biomed Papers, livedo reticularis can occur in pancreatic disorders, reflecting underlying vascular or inflammatory complications



Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making any changes to your health routine or treatment.



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