Secretary of State Marco Rubio refused to dismiss the possibility that the Cuban communist regime could become the Trump administration's next focus, just one day after Venezuelan dictator Nicolas Maduro's detention.

Rubio's Sunday alert emerged just hours after Maduro and his spouse, Cilia Flores, touched down in New York City, where they will confront charges for their purported involvement in a narco-terrorism conspiracy.

An indictment published by the Department of Justice accused Maduro of spearheading a "corrupt, illegitimate government that, for decades, has leveraged government power to protect and promote illegal activity, including drug trafficking." It also claims that the drug trafficking operations "enriched and entrenched Venezuela's political and military elite."

In an appearance on "Meet the Press," Rubio issued a stark warning to the Cuban authorities, declaring "they're in a lot of trouble. "Is the Cuban government the Trump administration's next target," journalist Kristen Welker enquired.

"Well, the Cuban government is a huge problem. Yeah," Rubio responded.

"Is that a yes?" Welker pressed.

"I think they're in a lot of trouble, yes," Rubio confirmed.

In another interview, Rubio, whose parents fled Cuba, alleged that Venezuela's intelligence service was "full of Cubans," and that "this poor island took over Venezuela.

"In some cases, one of the biggest problems Venezuelans have is they have to declare independence from Cuba," Rubio stated from President Trump's Mar-a-Lago resort. "They tried to basically colonize it from a security standpoint. So, yeah, look, if I lived in Havana and I was in the government, I'd be concerned at least a little bit."

At a Saturday news briefing, President Trump himself revealed that the U.S. was seeking to be surrounded by "good neighbors."

"It's very similar in the sense that we want to help the people in Cuba, but we want to also help the people who are forced out of Cuba and living in this country," the president declared.

Trump also branded the small island as a "failing nation" that is "not doing very well right now."

The Cuban government has yet to issue a response to Rubio's remarks.

Nevertheless, as a steadfast ally to Maduro's regime, Cuban officials have vehemently denounced the recent explosions and American operations in Caracas.

"All nations of the region must remain alert, as the threat hangs over all. In Cuba, our determination to struggle is firm and unwavering. The decision is one and only one: Homeland or Death," officials declared.

Venezuela's future hangs in the balance following these dramatic developments. According to Venezuelan law, the nation's vice president, Delcy Rodriguez, must step into Maduro's role following his detention.

Nevertheless, during a Saturday appearance, she insisted she would not take on the presidency, before Venezuela's supreme court mandated that she serve as interim leader. She has also called upon the Trump administration to release Maduro and Flores and send them back to their homeland.

"There is only one president in Venezuela," Rodriguez said, "and his name is Nicolas Maduro Moros."

At the same time, President Trump declared that his administration would "run" Venezuela throughout the transition, stating, "we're going to rebuild the oil infrastructure, which will cost billions of dollars; it will be paid for by the oil companies directly. And we're going to get the oil flowing the way it should be."