Scientists have discovered a protein in the immune system that can increase the chances of preventing multi-organ failure in patients suffering from severe liver injury.

Scientists have discovered a protein in the immune system that can increase the chances of preventing multi-organ failure in patients suffering from severe liver injury. Researchers said that damage in one part of the body increases the age of cells and their ability to function decreases, which can spread to other organs.

In the process that occurs with old age, called 'senescence', cells become tired and stop working properly. However, this process can also occur due to illness at any age. Senescence due to any serious disease in the liver cells can cause serious damage to this organ, which not only leads to liver failure but also multi-organ failure.

A team of researchers led by the University of Edinburgh, UK, researched mice and human liver tissue with severe liver disease. They found that when a large number of liver cells are damaged, the senescence process also shows up in other organs, such as the kidneys and lungs, increasing the risk of multi-organ failure and the need for a liver transplant.

The researchers identified a mechanism by a protein called TGFB, which is associated with the immune system. Blocking the activity of this protein can prevent liver cell damage from spreading to other organs. "We validated these new and exciting observations in patients by developing blood biomarkers to identify high-risk patients and identify new treatment options," said study author Rajiv Jalan, professor of hepatology at University College London, UK.

What is the expert's opinion?

There are currently no tests available to predict how liver failure will progress, but monitoring liver cells can identify patients who may need a transplant, the researchers said. "We have identified the TGFB pathway, an important mediator of transmission of senescence to other organs, and its blocking could prevent liver-induced kidney problems.

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