Beijing Beijing: A research team at the University of Tianzin, Northern China has developed a new type of injected hydrogel that can control immune cell metabolism, which helps reduce inflammation and slow down rheumatoid arthritis.

Rumetide arthritis is a painful and persistent chronic disease. This occurs when the body's immune system accidentally attacks healthy joints, causing distortion and disability, causing everyday life to millions of people, the Xinhua news agency said.

Scientists have found that an important factor in this process is the metabolism of immune cells, especially macrophages. When the metabolic tracts of these cells become unbalanced, they release highly inflammatory signs that further spoil the disease. If this metabolism can be controlled, it can open a new method of treating rheumatoid arthritis.

The new hydrogel biodegradable alginal developed by researchers is made up of a particular double network composition, making it easy to inject and allows controlled release of medical agents.

After entering the joint, the hydrogel reacts to the acidic environment of the inflamed area, gradually releases zinc ions and small interventions RNAs. These substances help re-program the metabolism of macrophages, which reduces their ability to trigger inflammation and increases their inflammatory function.

“This is the first time metabolic romograming has been used in the treatment of rheumatoid arthritis, and we hope that it can also be applied to other inflammatory diseases in the future,” said Lee Naan, the team leading the team.

The findings were recently published in advanced functional materials. “Our goal is not only to provide more effective treatment for RA, but also to search for new ways to deal with inflammation conditions at the metabolic level,” Nan said. Nan said. This Abhinav Hydrogenal RA brings new hope for patients, which provides potential game-visible in the fight against this challenging disease.