A pharmacist has revealed the potential pain-relieving properties of the type 2 diabetes drug Mounjaro, which could provide relief for millions of women battling endometriosis. This condition results in tissue akin to the lining of the uterus growing outside it.

The condition can lead to severe pelvic pain and potentially hinder fertility. Endometriosis can start with a woman's first menstrual cycle and persist until menopause.

A recent highlighted that endometriosis is forcing skilled women out of their jobs due to inadequate support and understanding from employers. Research indicates that women diagnosed with endometriosis often earn less due to decreased working hours. In some instances, they quit their jobs entirely because of the condition.

Hira Malik, co-founder and chief pharmacist at Oushk Pharmacy, and an expert in obesity, has shared her professional insights on how Mounjaro could be utilised to alleviate symptoms of endometriosis.

Mounjaro is a prescription-only treatment for type 2 diabetes, reports . It contains the active ingredient tirzepatid, which functions by activating two receptors known as GLP-1 and GIP to increase the level of incretin hormones in the body. Doctors primarily prescribe Mounjaro to help reduce blood sugar levels, alongside diet and physical activity, in individuals diagnosed with type 2 diabetes.

Mounjaro, a relatively new drug, may be used for other conditions as determined by your GP. It's suggested that Mounjaro might help alleviate some people's endometriosis symptoms, due to its potential anti-inflammatory properties. However, given the complex relationship between weight and endometriosis compared to other health conditions, further studies are needed to substantiate these claims.

Endometriosis is a chronic and often debilitating condition affecting one in ten women in the UK. Symptoms include severe pelvic pain, inflammation, fatigue, and hormonal imbalances, which can significantly impact quality of life.

Some health experts believe weight management and metabolic health are crucial in controlling these symptoms. Mounjaro's potential effects on appetite regulation, insulin sensitivity, and weight loss could be an unexpected tool for some individuals managing the condition.

Hira Malik suggests there may be potential benefits of Mounjaro in supporting women with endometriosis. While the medication is primarily licensed for managing type 2 diabetes, emerging insights suggest it could help with some of the metabolic and hormonal challenges that accompany endometriosis.

Hira has made it clear that while "Mounjaro is not a treatment for endometriosis itself," it could be instrumental in managing related issues. She said: "However, many women with the condition struggle with weight fluctuations, insulin resistance, and systemic inflammation, all of which can exacerbate symptoms. By helping to regulate appetite, blood sugar levels, and metabolic function, Mounjaro may support a holistic approach to managing endometriosis."

The importance of weight management cannot be overstated when it comes to hormonal balance and reducing inflammation. Being overweight can lead to increased oestrogen levels, potentially aggravating endometriosis symptoms.

Insulin resistance-a common issue among those with endometriosis-can cause energy dips, intense cravings, and additional inflammation.

Hira stresses the necessity of medical guidance when considering Mounjaro, advocating for its use as part of a comprehensive approach to symptom management. This strategy might encompass hormone therapies, pain relief measures, and modifications in lifestyle.

She further elaborates on the multifaceted nature of managing endometriosis symptoms: "Managing endometriosis symptoms is about finding the right combination of medical treatments, lifestyle adjustments, and metabolic support." She added: "We have seen that for some women, achieving a healthier weight and improving insulin sensitivity can contribute to better symptom control and improved daily well-being.

"Many experience intense food cravings, particularly around their menstrual cycles, making it difficult to maintain balanced nutrition. By regulating appetite and preventing overeating, Mounjaro could help support healthier eating habits.

"Additionally, for those who struggle with weight management due to hormonal imbalances or pain that limits physical activity, it may provide extra support in achieving a healthy weight. Mounjaro also improves insulin sensitivity, which may positively impact energy levels, reduce inflammation, and support overall metabolic health."

Experts suggest that effectively managing symptoms of endometriosis and polycystic ovary syndrome (PCOS) - a common hormonal disorder in women - can hinge on maintaining a healthy body mass. Slimming down may significantly alter hormone production, potentially leading to more regular menstrual cycles.

Even reducing one's weight by . A report from one indicates an average body weight reduction of 17% for participants administered 10mg of Mounjaro and a substantial 15% loss for those using a smaller 5mg dose of the drug.

This medicine is licensed for treating obesity and type 2 diabetes and is used in conjunction with diet and exercise. Mounjaro is designed to help maintain blood sugar levels within a healthy range. It lowers blood sugar through several mechanisms. When blood sugar (glucose) levels rise, it boosts insulin production in your body.

Insulin is a hormone that allows your body to use glucose for energy. Mounjaro also prevents your liver from releasing stored sugar into the bloodstream, slowing down the absorption of food and drinks you consume.

Mounjaro could also help with weight management by controlling appetite, promoting a feeling of fullness, curbing cravings, and helping users eat smaller portions.

The most common side effects of Mounjaro include:

• Nausea.
• Diarrhoea.
• Decreased appetite.
• Vomiting.
• Constipation.
• Upset stomach or stomach pain.

While less frequent, Mounjaro still has some serious side effects. The drug may cause allergic reactions, thyroid tumours, inflammation of the pancreas, low blood sugar when used with other diabetes drugs, kidney damage, gallbladder problems and vision changes.

Mounjaro is not used to treat type 1 diabetes. Do not use Mounjaro unless a healthcare provider has prescribed it to you.

The effect of alcohol on Mounjaro is not well understood, but it can affect blood sugar levels in people with diabetes. This could potentially interfere with Mounjaro's effectiveness. It's advisable to cut down on your alcohol consumption.