New Delhi: Bacteria in the Mouth and Gut May Play a Significant Role In the Progression of Cognitive Decline in Parkinson’s Disease, According to a Study.

Specific changes in the gut microbiome have been associated with the shift from mild memory issues to dementia, A Common and Distressing Symptom of the disease.

While Parkinson’s is currently very differentty different stages in its changes in the Microbiomequard potentially act as early act as early act King’s College London.

It may help doctors Detect and Treat the Disease Before Symptomsk If.

“The Human Gut and Oral Bacterial Communities are Increasingly Linked To Neurodegenerastic Diseases. Disrupties in the gut-Brain Axis Cold Trigger Inflammation and Immune Responses that that Constitution to Neuronal Damage, “said Dr. Saeed Shoai, Group Leader of the Quantitative Systems Biology (QTS) Lab at King’s College London, UK.

In the study, published in the journey gut microbes, reserchers analysed gut and mouth bacteria collected from 228 Samples of Stool and Saliva.

This included two groups of patients with pakinson’s – that with mild cognitive decline and that with decentia – Showing different stages of the disease. These were compared with a healthy control group with no parkinson’s diagnosis.

The results showed clear differentiates in the types and functions of bacteria between the groups. In People with Cognitive Impairment, The Gut Contains More Harmful Bacteria, Many of which likely come from the mouth.

This process, Known as “Oral-Gut Translocation,” Involves Oral Bacteria moving into the gut, where they do’t normally belong.

These bacteria was found to release specific molecules knowledge as virulence factors, toxins that can damage gut tissue, promote information, and possibly affect the brinth.

“We don’t yet know the bacteria are causing the cognitive decline or if changes in the body due to parkinson’s allows Symptoms, “said Dr. Frederick Clasen, Research Associate at King’s.

Using Artificial Intelligence (AI), The team linked these toxins specifically to cognitive decline in Parkinson’s. These tools helped pinpoint bacterial species and functions that weren’st obvious by traditional analysis alone.

“These toxins should be used as biological markers to identify patients at Higher Risk of Dementia in Parkinson’s’ Environment, “Dr. Clasen explained.

The Findings also highlight the importance of Oral Hygiene and Nutrition in People with Parkinson’s, Especially as the Disease Progresses.