"The two major earthquakes that just hit the great people of Venezuela are both massive in scale and have left a devastating number of deaths," Trump posted on his Truth Social platform.
"The USA stands ready, willing, and able to help! I have instructed all agencies of our government to get ready to move quickly. We will be there for our new and great friends. Early reports are not good!!!"
Venezuela has not released the number of casualties or extent of the destruction.
US is sending assistance to Venezuela, officials say
US Deputy Secretary of State Christopher Landau announced that the US was in touch with Venezuelan authorities following two massive earthquakes in the South American country.
"The US stands with the Venezuelan people in the aftermath of this evening’s devastating earthquakes," Landau wrote on X.
He said that Washington was mobilizing assistance for Venezuela.
US Under Secretary of State for Foreign Assistance Jeremy Lewin said the US had already deployed a disaster assistance team and was coordinating critical assistance for people affected by the earthquakes.
"The US will be sending search and rescue teams, medical and humanitarian supplies and other resources in the crucial first days after this tragic natural disaster," he wrote on X.
US Embassy issues safety alert to citizens
The United States Embassy in Caracas said it was "closely monitoring" the situation after two powerful quakes hit central Venezuela on Wednesday.
The US Embassy urged American citizens in a post on X to "avoid damaged areas and do not enter damaged buildings" and "seek secure shelter."
The embassy also asked people to monitor both the US State Department website and local media websites.
The two earthquakes of magnitude 7.2 and 7.5 destroyed buildings in Caracas and drove people into the streets.
