Delhi : Chemotherapy is a major method in cancer treatment, but in many cases it is not effective. Scientists behind this failure “Chemotherapy resistance” Has recognized as a major problem. recently, Mass General Brigham Scientists of the scientists did an important research on the subject, in which he discovered that cancer cells Protein called vps35 You can avoid chemotherapy with the help of.
This research is the prestigious science magazine “Nature” Has been published in The study revealed that VPS35 mutation Reactive Oxygen Species – ROS Reduces the levels of, causing cancer cells to avoid chemotherapy.
After this discovery, it can now be possible whether doctors can investigate the VPS35 level of patients and guess whether chemotherapy will affect their cancer tumors.
Chemotherapy is to destroy cancer cells, but when Cancer cells become resistant to drugs over timeSo this treatment becomes neutralized.
What does research say?
ROS molecules help in the general functions of cells, but They can destroy cells when they are in excess।
Some cancer cells Vps35 protein With the help of the ROS levels reduce the level of ROS.
Due to this, chemotherapy is not able to affect them and cancer tumors continue to grow.
Prominent scientists of this research Liron Bar-Peled Said, “The clear understanding of ROS can help us know why chemotherapy fails in some cases.”
Scientists to understand the impact of VPS35 High-grade serous ovarian cancer-HGSOC Suffering from 24 patients Analyzed the tumor.
The study found: 
in patients VPS35 level high Was in them Chemotherapy more effective doing. Lower level of VPS35 Low treatment reaction and the possibility of less survival Was associated with VPS35 Mutation of Cancer Cells ROS level decreasesWhich helps the tumor to avoid chemotherapy.
This means that in the future By examining VPS35, doctors will be able to find out in advance whether chemotherapy will affect the patient or not.
Personalized treatment: The cancer cells of each patient are different. VPS35 examined Doctors can decide that for a patient Chemotherapy is the right choice or not.
Development of new drugs: Now scientists can develop such medicines that target VPS35 mutation Can make chemotherapy more effective.
Cancer treatment success rate will increase: If VPS35 level is examined before chemotherapy, for cancer The most appropriate treatment can be planned.
Researcher Liron Bar-Pailed Is said, “Our findings may increase the chances of personal treatment of cancer. We can decide which treatment will be most effective for them by examining the patient's VPS35 level.”
Cancer experts believe that This discovery can bring revolutionary changes in cancer treatment.
This research towards understanding chemotherapy resistance An important achievement Is. Scientists hope that Personalized Medicine will be promoted in the treatment of cancer.
By examining the level of VPS35 protein, doctors will be able to determine in future that For which patients, chemotherapy will be the right choice and which will require alternative treatment.
This discovery has raised new expectations in cancer treatment, and in the coming years this discovery can play a big role in saving the lives of patients.
